MicroRNAs in human skin ageing.

Autor: Mancini M; University of 'Tor Vergata', Department of Experimental Medicine and Surgery, Via Montpellier 1, Rome 00133, Italy., Lena AM; University of 'Tor Vergata', Department of Experimental Medicine and Surgery, Via Montpellier 1, Rome 00133, Italy., Saintigny G; CHANEL Parfums Beauté, F-92521 Neuilly/Seine, France., Mahé C; CHANEL Parfums Beauté, F-92521 Neuilly/Seine, France., Di Daniele N; University of 'Tor Vergata', Department of Systems Medicine, Via Oxford 1, Rome 00133, Italy., Melino G; University of 'Tor Vergata', Department of Experimental Medicine and Surgery, Via Montpellier 1, Rome 00133, Italy; IDI-IRCCS, Via Monti di Creta 104, Rome 00166, Italy., Candi E; University of 'Tor Vergata', Department of Experimental Medicine and Surgery, Via Montpellier 1, Rome 00133, Italy. Electronic address: candi@uniroma2.it.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2014 Sep; Vol. 17, pp. 9-15. Date of Electronic Publication: 2014 Apr 28.
DOI: 10.1016/j.arr.2014.04.003
Abstrakt: The skin protects humans from the surrounding environment. Tissues undergo continuous renewal throughout an individual's lifetime; however, there is a decline in the regenerative potential of tissue with age. The accumulation of senescent cells over time probably reduces tissue regenerative capacity and contributes to the physiological ageing of the tissue itself. The mechanisms that govern ageing remain unclear and are under intense investigation, and insight could be gained by studying the mechanisms involved in cellular senescence. In vitro, keratinocytes and dermal fibroblasts undergo senescence in response to multiple cellular stresses, including the overproduction of reactive oxygen species and the shortening of telomeres, or simply by reaching the end of their replicative potential (i.e., reaching replicative senescence). Recent findings demonstrate that microRNAs play key roles in regulating the balance between a cell's proliferative capacity and replicative senescence. Here, we will focus on the molecular mechanisms regulated by senescence-associated microRNAs and their validated targets in both keratinocytes and dermal fibroblasts.
(Copyright © 2014 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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