α-Glucosidase inhibitory activities of isoflavanones, isoflavones, and pterocarpans from Mucuna pruriens.
| Autor: | Dendup T; Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand., Prachyawarakorn V; Chulabhorn Research Institute, Bangkok, Thailand., Pansanit A; Chulabhorn Research Institute, Bangkok, Thailand., Mahidol C; Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand., Ruchirawat S; Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand., Kittakoop P; Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand. |
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| Jazyk: | angličtina |
| Zdroj: | Planta medica [Planta Med] 2014 May; Vol. 80 (7), pp. 604-8. Date of Electronic Publication: 2014 Apr 29. |
| DOI: | 10.1055/s-0034-1368427 |
| Abstrakt: | Three new isoflavanones (1-3) and thirteen known compounds (4-16) were isolated from the roots of Mucuna pruriens. The absolute configurations of isoflavanones 1-3 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent. (Georg Thieme Verlag KG Stuttgart · New York.) |
| Databáze: | MEDLINE |
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