Nanophotonic trapping for precise manipulation of biomolecular arrays.

Autor:	Soltani M; 1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA [3]., Lin J; 1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA [3]., Forties RA; 1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA., Inman JT; Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA., Saraf SN; Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA., Fulbright RM; Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA., Lipson M; 1] Department of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, USA [2] Kavli Institute at Cornell University, Ithaca, New York 14853, USA., Wang MD; 1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA.
Jazyk:	angličtina
Zdroj:	Nature nanotechnology [Nat Nanotechnol] 2014 Jun; Vol. 9 (6), pp. 448-52. Date of Electronic Publication: 2014 Apr 28.
DOI:	10.1038/nnano.2014.79
Abstrakt:	Optical trapping is a powerful manipulation and measurement technique widely used in the biological and materials sciences. Miniaturizing optical trap instruments onto optofluidic platforms holds promise for high-throughput lab-on-a-chip applications. However, a persistent challenge with existing optofluidic devices has been achieving controlled and precise manipulation of trapped particles. Here, we report a new class of on-chip optical trapping devices. Using photonic interference functionalities, an array of stable, three-dimensional on-chip optical traps is formed at the antinodes of a standing-wave evanescent field on a nanophotonic waveguide. By employing the thermo-optic effect via integrated electric microheaters, the traps can be repositioned at high speed (∼30 kHz) with nanometre precision. We demonstrate sorting and manipulation of individual DNA molecules. In conjunction with laminar flows and fluorescence, we also show precise control of the chemical environment of a sample with simultaneous monitoring. Such a controllable trapping device has the potential to achieve high-throughput precision measurements on chip.
Databáze:	MEDLINE
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