Morphological and functional aspects of acute kidney injury after fetal programing in the offspring of diabetic rats.

Autor:	Pucci KR; General Pathology Discipline ., Pereira Júnior CD, Idaló PB, Moreira AC, Rocha LP, Rodrigues AR, Reis LC, Gomes RA, Rocha LB, Guimarães CS, Reis MA, Câmara NO, Corrêa RR
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2015 Mar; Vol. 28 (4), pp. 403-8. Date of Electronic Publication: 2014 May 27.
DOI:	10.3109/14767058.2014.918097
Abstrakt:	Objective: To evaluate the effects of folic acid (FA)-induced renal failure in young offspring of diabetic mothers. Methods: The offspring of streptozotocin-induced diabetic dams were divided into four groups: CC (controls receiving vehicle); DC (diabetics receiving vehicle); CA (controls receiving FA solution, 250 mg/kg) and DA (diabetics receiving FA solution, 250 mg/kg). Renal function tests and morphometry results were analyzed. Results: An increase in creatinine and urea levels was observed in CA and DA groups at two and five months. FA administration caused a significant reduction in the number of glomeruli in the offspring of diabetic dams. The diabetes group treated with FA had fewer glomeruli compared to controls at two and five months. FA caused an increase in the area of the urinary space both in controls and offspring of diabetic dams at two and five months. The number of glomeruli and area of the urinary space at two months were negatively correlated. Conclusions: Fetal programing promotes remarkable changes in kidney morphology and function in offspring. We suggest that the morphological changes in the kidneys are more pronounced when fetal programing is associated with newly acquired diseases, e.g. renal failure induced by FA.
Databáze:	MEDLINE
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