Evaluation of inner retinal layers in eyes with temporal hemianopic visual loss from chiasmal compression using optical coherence tomography.

Autor:	Monteiro ML; Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil., Hokazono K; Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil., Fernandes DB; Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil., Costa-Cunha LV; Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil., Sousa RM; Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil., Raza AS; Department of Psychology, Columbia University, New York, New York, United States Department of Neurobiology and Behavior, Columbia University, New York, New York, United States., Wang DL; Department of Psychology, Columbia University, New York, New York, United States., Hood DC; Department of Psychology, Columbia University, New York, New York, United States Department of Ophthalmology, Columbia University, New York, New York, United States.
Jazyk:	angličtina
Zdroj:	Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2014 Apr 24; Vol. 55 (5), pp. 3328-36. Date of Electronic Publication: 2014 Apr 24.
DOI:	10.1167/iovs.14-14118
Abstrakt:	Purpose: We measured macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and correlated these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve. Methods: Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were assessed qualitatively for microcysts in the INL. The VF was estimated from the central 16 test points. The two groups were compared. Correlations between VF and OCT measurements were assessed. Results: The mRNFL, RGCL+, and total retinal (TR) macular thickness measurements were significantly smaller in BA eyes than controls. In the nasal quadrants, INL measurements were significantly greater in BA eyes than controls. The mRNFL and RGCL+ measurements had greater discrimination ability than TR measurements in the temporal quadrants. A significant correlation was found between most OCT parameters and their corresponding VF parameters. The strongest association was observed between RNFL and RGCL+ thickness, and VF loss in the corresponding area. The INL microcysts were found in seven eyes with BA, but not in controls. Conclusions: Band atrophy leads to mRNFL and RGCL+ thinning, and INL thickening, and mRNFL and RGCL+ measurements are correlated strongly with VF loss. Segmented macular thickness measurements may be useful for quantifying neuronal loss in chiasmal compression. (Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.)
Databáze:	MEDLINE
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