Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma.

Autor: Ramos CS; Master's Program in Genetics, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil., Gonçalves AS; Department of Stomatology [Oral Pathology], Dental School, Federal University of Goiás, Goiânia, Goiás 74000, Brazil., Marinho LC; Departament of Medicine, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil., Gomes Avelino MA; Departament of Medicine, Federal University of Goiás, Goiânia, Goiás 74000, Brazil., Saddi VA; Master's Program in Genetics, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil; Departament of Medicine, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil; Laboratory of Oncogenetics and Radiobiology, Association of Cancer Combat in Goiás, Brazil., Lopes AC; Departament of Medicine, Pontifical Catholic University of Goiás, Goiânia, Goiás 74000, Brazil., Simões RT; Institute of Education and Research, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais 31000, Brazil., Wastowski IJ; Department of Biology, State University of Goiás, Morrinhos, Goiás 75000, Brazil. Electronic address: wastowski@gmail.com.
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2014 Jul; Vol. 75 (7), pp. 667-72. Date of Electronic Publication: 2014 Apr 20.
DOI: 10.1016/j.humimm.2014.04.005
Abstrakt: The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus, the aim of this study was to evaluate the frequency of 14-bp insertion/deletion HLA-G polymorphism, as well as the expression of this molecule in patients with invasive breast ductal carcinoma (IDC). A significant association between the expression of HLA-G and the presence of metastasis in lymph nodes (p=0.01) was observed and the expression of HLA-G was significantly higher in patients with shorter survival time (p=0.03). The analysis suggests that the polymorphism observed in patients with IDC may be inducing a higher expression of the HLA-G molecule, which may possibly contribute to shorter survival time and a worse clinical prognosis for such patients.
(Copyright © 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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