| Autor: |
Eadara JK; Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224., Dalrymple RH, DeLay RL, Ricks CA, Romsos DR |
| Jazyk: |
angličtina |
| Zdroj: |
Metabolism: clinical and experimental [Metabolism] 1989 Sep; Vol. 38 (9), pp. 883-90. |
| DOI: |
10.1016/0026-0495(89)90236-9 |
| Abstrakt: |
Fractional accretion rates of total body 3-methylhistidine containing proteins (actin and myosin) were elevated 40% to 120% in rats fed a high-carbohydrate diet containing 10 or 100 ppm cimaterol for 1 week. Fractional degradation and fractional synthesis rates of these proteins were examined by measuring total body 3-methylhistidine content and urinary excretion of 3-methylhistidine. Consumption of the diet containing 100 ppm cimaterol for 1 week caused a 25% reduction in fractional degradation rates and a concomitant 32% increase in fractional synthesis rates of 3-methylhistidine containing proteins. Effects of cimaterol on fractional accretion, degradation, and synthesis rates of 3-methylhistidine containing proteins diminished after 1 week. Cimaterol failed to influence plasma insulin, triiodothyronine, or corticosterone concentrations. The dramatic increase in accretion of 3-methylhistidine containing proteins observed during the first week rats are fed diets containing cimaterol is caused by reciprocal action on protein degradation and synthesis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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