Oxidative stress and its downstream signaling in aging eyes.

Autor:	Pinazo-Durán MD; Ophthalmic Research Unit 'Santiago Grisolía', Valencia, Spain., Gallego-Pinazo R; Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain., García-Medina JJ; Ophthalmic Research Unit 'Santiago Grisolía', Valencia, Spain ; Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain., Zanón-Moreno V; Ophthalmic Research Unit 'Santiago Grisolía', Valencia, Spain ; Faculty of Medicine, University of Valencia, Spain., Nucci C; University of Rome Tor Vergata, Rome, Italy., Dolz-Marco R; Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain., Martínez-Castillo S; Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain., Galbis-Estrada C; Ophthalmic Research Unit 'Santiago Grisolía', Valencia, Spain., Marco-Ramírez C; Ophthalmic Research Unit 'Santiago Grisolía', Valencia, Spain., López-Gálvez MI; Instituto de Oftalmobiología Aplicada (IOBA), Valladolid, Spain., Galarreta DJ; Instituto de Oftalmobiología Aplicada (IOBA), Valladolid, Spain., Díaz-Llópis M; Faculty of Medicine, University of Valencia, Spain.
Jazyk:	angličtina
Zdroj:	Clinical interventions in aging [Clin Interv Aging] 2014 Apr 11; Vol. 9, pp. 637-52. Date of Electronic Publication: 2014 Apr 11 (Print Publication: 2014).
DOI:	10.2147/CIA.S52662
Abstrakt:	Background: Oxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury. Objective: We reviewed the role of OS and its downstream signaling in aging eyes. Methods: A search of the literature and current knowledge on the physiological and pathological mechanisms of OS were revisited in relation to the eyes and the aging process. Most prevalent ocular diseases have been analyzed herein in relation to OS and nutraceutic supplements, such as dry-eye disorders, glaucoma, age-related macular degeneration, and diabetic retinopathy. Results: Clinical, biochemical, and molecular data from anterior and posterior eye segment diseases point to OS as the common pathogenic mechanism in the majority of these ocular disorders, many of which are pathologies causing visual impairment, blindness, and subsequent loss of life quality. Studies with nutraceutic supplements in aging eye-related pathologies have also been reviewed. Conclusion: OS, nutritional status, and nutraceutic supplements have to be considered within the standards of care of older ophthalmologic patients. OS biomarkers and surrogate end points may help in managing the aging population with ocular diseases.
Databáze:	MEDLINE
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