Human immunodeficiency virus type 1 (HIV-1) subtype B epidemic in Panama is mainly driven by dissemination of country-specific clades.
Autor: | Mendoza Y; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama; Department of Biotechnology, Acharya Nagarjuna University, Guntur City, Andhra Pradesh, India; Department of Genetics and Molecular Biology, University of Panama, Panama City, Panama; INDICASAT-AIP, City of Knowledge, Clayton, Panama City, Panama., Martínez AA; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama; Department of Biotechnology, Acharya Nagarjuna University, Guntur City, Andhra Pradesh, India; INDICASAT-AIP, City of Knowledge, Clayton, Panama City, Panama., Castillo Mewa J; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama., González C; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama., García-Morales C; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Avila-Ríos S; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Reyes-Terán G; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Armién B; Department of Emerging and Zoonotic Infectious Diseases, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Pascale JM; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Bello G; Laboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. |
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Jazyk: | angličtina |
Zdroj: | PloS one [PLoS One] 2014 Apr 18; Vol. 9 (4), pp. e95360. Date of Electronic Publication: 2014 Apr 18 (Print Publication: 2014). |
DOI: | 10.1371/journal.pone.0095360 |
Abstrakt: | The Human immunodeficiency virus type-1 (HIV-1) subtype B is the most predominant clade in Central America; but information about the evolutionary history of this virus in this geographic region is scarce. In this study, we reconstructed the spatiotemporal and population dynamics of the HIV-1 subtype B epidemic in Panama. A total of 761 HIV-1 subtype B pol sequences obtained in Panama between 2004 and 2013 were combined with subtype B pol sequences from the Americas and Europe. Maximum Likelihood phylogenetic analyses revealed that HIV-1 subtype B infections in Panama derived from the dissemination of multiple founder viruses. Most Panamanian subtype B viruses (94.5%) belong to the pandemic viral strain proposed as originated in the US, whereas others (5.5%) were intermixed among non-pandemic Caribbean strains. The bulk (76.6%) of subtype B sequences from Panama grouped within 12 country-specific clades that were not detected in other Central American countries. Bayesian coalescent-based analyses suggest that most Panamanian clades probably originated between the early 1970s and the early 1980s. The root location of major Panamanian clades was traced to the most densely populated districts of Panama province. Major Panamanian clades appear to have experienced one or two periods of exponential growth of variable duration between the 1970s and the 2000s, with median growth rates from 0.2 to 0.4 year(-1). Thus, the HIV-1 subtype B epidemic in Panama is driven by the expansion of local viral strains that were introduced from the Caribbean and other American countries at an early stage of the AIDS pandemic. |
Databáze: | MEDLINE |
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