The influence of neuropathology on brain inflammation in human and experimental temporal lobe epilepsy.

Autor: Aalbers MW; School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands. Electronic address: mwaalbers@gmail.com., Rijkers K; School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurosurgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Majoie HJ; School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands; Epilepsy Centre Kempenhaeghe, PO Box 61, 5590 AB Heeze, The Netherlands., Dings JT; Department of Neurosurgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Schijns OE; Department of Neurosurgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Schipper S; School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands., De Baets MH; School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands., Kessels A; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Vles JS; School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Hoogland G; School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurosurgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2014 Jun 15; Vol. 271 (1-2), pp. 36-42. Date of Electronic Publication: 2014 Mar 29.
DOI: 10.1016/j.jneuroim.2014.03.016
Abstrakt: It is unclear to what extent neuropathological changes contribute to brain inflammation observed in temporal lobe epilepsy (TLE). Here, we compared cytokine levels between histopathologically-confirmed sclerotic hippocampi and histopathologically-confirmed normal hippocampi from TLE patients. We analyzed a similar cytokine panel in the hippocampi of amygdala-kindled rats and we evaluated neuropathological changes by immunohistochemistry. In TLE patients, cytokine levels were not significantly different between sclerotic and non-sclerotic hippocampi. Though kindling resulted in increased astrocyte activation, cytokine levels and microglia activation were unchanged. These results suggest that the chronic epileptic state in TLE can also occur in the absence of intracerebral inflammation. Highlights.
(Copyright © 2014 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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