Congenital hypothyroidism in neonates.
| Autor: | Anjum A; Department of Paediatrics, King Edward Medical University/Mayo Hospital, Lahore, Pakistan., Afzal MF; Department of Paediatrics, King Edward Medical University/Mayo Hospital, Lahore, Pakistan., Iqbal SM; Department of Paediatrics, King Edward Medical University/Mayo Hospital, Lahore, Pakistan., Sultan MA; Department of Paediatrics, King Edward Medical University/Mayo Hospital, Lahore, Pakistan., Hanif A; Department of Biostatistics, PGMI, Gulab Devi Hospital, Lahore, Pakistan. |
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| Jazyk: | angličtina |
| Zdroj: | Indian journal of endocrinology and metabolism [Indian J Endocrinol Metab] 2014 Mar; Vol. 18 (2), pp. 213-6. |
| DOI: | 10.4103/2230-8210.129114 |
| Abstrakt: | Context: Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation in children and it occurs in approximately 1:2,000-1:4,000 newborns. Aims and Objectives: The aim of this study is to determine the frequency of CH in neonates. Settings and Design: This cross-sectional study was conducted in neonatal units of the Department of Pediatrics Unit-I, King Edward Medical University/Mayo Hospital, Lahore and Lady Willington Hospital Lahore in 6 months (January-June 2011). Materials and Methods: Sample was collected by non-probability purposive sampling. After consent, 550 newborn were registered for the study. Demographic data and relevant history was recorded. After aseptic measures, 2-3 ml venous blood analyzed for thyroid-stimulating hormone (TSH) level by immunoradiometric assay. Treatment was started according to the individual merit as per protocol. Statistical Analysis Used: Data was analyzed by SPSS 17 and Chi-square test was applied to find out the association of CH with different variables. Results: The study population consisted of 550 newborns. Among 550 newborns, 4 (0.8%) newborns had elevated TSH level. CH had statistically significant association with mother's hypothyroidism (P value 0.000) and mother's drug intake during the pregnancy period (P value 0.013). Conclusion: CH is 0.8% in neonates. It has statistically significant association with mother's hypothyroidism and mother's drug intake during pregnancy. |
| Databáze: | MEDLINE |
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