| Autor: |
Hinton EA; Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia 30329, USA., Wheeler MG, Gourley SL |
| Jazyk: |
angličtina |
| Zdroj: |
Learning & memory (Cold Spring Harbor, N.Y.) [Learn Mem] 2014 Apr 15; Vol. 21 (5), pp. 253-7. Date of Electronic Publication: 2014 Apr 15. |
| DOI: |
10.1101/lm.033290.113 |
| Abstrakt: |
An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited-or "habitual"-qualities that are resistant to change. We show that selective knockdown of prelimbic prefrontal cortical Brain-derived neurotrophic factor (Bdnf) increases sensitivity to response-outcome associations, blocking habit-like behavioral inflexibility. A history of adolescent cocaine exposure, however, occludes the "beneficial" effects of Bdnf knockdown. This finding highlights a challenge in treating addiction-that drugs of abuse may bias decision-making toward habit systems even in individuals with putative neurobiological resiliencies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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