Bone marrow edema on magnetic resonance imaging (MRI) of the sacroiliac joints is associated with development of fatty lesions on MRI over a 1-year interval in patients with early inflammatory low back pain: a 2-year followup study.

Autor:	van Onna M; From the School for Public Health and Primary Care (CAPHRI), University of Maastricht, and Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Immunology and Rheumatology, Academic Medical Center Amsterdam, Amsterdam; Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands.M. van Onna, MD; A. van Tubergen, MD, PhD, Department of Medicine, Division of Rheumatology, Maastricht University Medical Center; D.M. van der Heijde, MD, PhD, Leiden University Medical Center; A.G. Jurik, MD, PhD, Aarhus University Hospital; R. Landewé, MD, PhD, Academic Medical Center Amsterdam, and Department of Rheumatology, Atrium Medical Center Heerlen. m.van.onna@mumc.nl., van Tubergen A; From the School for Public Health and Primary Care (CAPHRI), University of Maastricht, and Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Immunology and Rheumatology, Academic Medical Center Amsterdam, Amsterdam; Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands.M. van Onna, MD; A. van Tubergen, MD, PhD, Department of Medicine, Division of Rheumatology, Maastricht University Medical Center; D.M. van der Heijde, MD, PhD, Leiden University Medical Center; A.G. Jurik, MD, PhD, Aarhus University Hospital; R. Landewé, MD, PhD, Academic Medical Center Amsterdam, and Department of Rheumatology, Atrium Medical Center Heerlen., van der Heijde DM; From the School for Public Health and Primary Care (CAPHRI), University of Maastricht, and Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Immunology and Rheumatology, Academic Medical Center Amsterdam, Amsterdam; Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands.M. van Onna, MD; A. van Tubergen, MD, PhD, Department of Medicine, Division of Rheumatology, Maastricht University Medical Center; D.M. van der Heijde, MD, PhD, Leiden University Medical Center; A.G. Jurik, MD, PhD, Aarhus University Hospital; R. Landewé, MD, PhD, Academic Medical Center Amsterdam, and Department of Rheumatology, Atrium Medical Center Heerlen., Jurik AG; From the School for Public Health and Primary Care (CAPHRI), University of Maastricht, and Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Immunology and Rheumatology, Academic Medical Center Amsterdam, Amsterdam; Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands.M. van Onna, MD; A. van Tubergen, MD, PhD, Department of Medicine, Division of Rheumatology, Maastricht University Medical Center; D.M. van der Heijde, MD, PhD, Leiden University Medical Center; A.G. Jurik, MD, PhD, Aarhus University Hospital; R. Landewé, MD, PhD, Academic Medical Center Amsterdam, and Department of Rheumatology, Atrium Medical Center Heerlen., Landewé R; From the School for Public Health and Primary Care (CAPHRI), University of Maastricht, and Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Immunology and Rheumatology, Academic Medical Center Amsterdam, Amsterdam; Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands.M. van Onna, MD; A. van Tubergen, MD, PhD, Department of Medicine, Division of Rheumatology, Maastricht University Medical Center; D.M. van der Heijde, MD, PhD, Leiden University Medical Center; A.G. Jurik, MD, PhD, Aarhus University Hospital; R. Landewé, MD, PhD, Academic Medical Center Amsterdam, and Department of Rheumatology, Atrium Medical Center Heerlen.
Jazyk:	angličtina
Zdroj:	The Journal of rheumatology [J Rheumatol] 2014 Jun; Vol. 41 (6), pp. 1088-94. Date of Electronic Publication: 2014 Apr 15.
DOI:	10.3899/jrheum.131022
Abstrakt:	Objective: To assess whether bone marrow edema (BME) detected on magnetic resonance imaging (MRI) of the sacroiliac joints (MRI-SIJ) is associated with development of structural changes on both MRI and pelvic radiographs in patients with early inflammatory back pain (IBP). Methods: Patients with IBP ≤ 2 years were followed for 2 years with annual MRI-SIJ. MRI were scored for BME and structural changes (erosions and fatty lesions). Pelvic radiographs were graded according to the modified New York (mNY) criteria. With generalized estimated equation analysis, a time trend in the structural change scores was investigated. Results: Sixty-eight patients [38% male; mean (SD) age 34.9 (10.3) yrs] were included. During the 2-year followup, pelvic radiograph grading remained constant. On MRI, the number of erosions per patient increased significantly (mean score 2.5 at baseline and 3.5 at 2-yr followup; p = 0.05). A trend was found for an increase in the number of fatty lesions per patient (mean score 5.4 at baseline and 8.5 at 2-yr followup; p = 0.06). Overall, BME was associated with the development of fatty lesions (right SIJ: OR 3.13, 95% CI 1.06-9.20; left SIJ: OR 22.13, 95% CI 1.27-384.50), preferentially in quadrants showing resolution of BME. In contrast, BME (or the resolution thereof) was not associated with the development of erosions. Conclusion: BME at baseline, especially when it disappears over time, results in the development of fatty lesions, but an association with erosions could not be demonstrated.
Databáze:	MEDLINE
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