Topological methods reveal high and low functioning neuro-phenotypes within fragile X syndrome.
| Autor: | Romano D; Center for Interdisciplinary Brain Sciences Research, Stanford University Medical School, Stanford, California., Nicolau M, Quintin EM, Mazaika PK, Lightbody AA, Cody Hazlett H, Piven J, Carlsson G, Reiss AL |
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| Jazyk: | angličtina |
| Zdroj: | Human brain mapping [Hum Brain Mapp] 2014 Sep; Vol. 35 (9), pp. 4904-15. Date of Electronic Publication: 2014 Apr 15. |
| DOI: | 10.1002/hbm.22521 |
| Abstrakt: | Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability as well as the most common single-gene risk factor for autism. Our goal was to examine variation in brain structure in FXS with topological data analysis (TDA), and to assess how such variation is associated with measures of IQ and autism-related behaviors. To this end, we analyzed imaging and behavioral data from young boys (n = 52; aged 1.57-4.15 years) diagnosed with FXS. Application of topological methods to structural MRI data revealed two large subgroups within the study population. Comparison of these subgroups showed significant between-subgroup neuroanatomical differences similar to those previously reported to distinguish children with FXS from typically developing controls (e.g., enlarged caudate). In addition to neuroanatomy, the groups showed significant differences in IQ and autism severity scores. These results suggest that despite arising from a single gene mutation, FXS may encompass two biologically, and clinically separable phenotypes. In addition, these findings underscore the potential of TDA as a powerful tool in the search for biological phenotypes of neuropsychiatric disorders. (Copyright © 2014 Wiley Periodicals, Inc.) |
| Databáze: | MEDLINE |
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