| Autor: |
Chiarotto GB; School of Biomedicine, Herminio Ometto University Center, UNIARARAS, Av. Maximiliano Baruto, 500, Araras, SP , 13607-339, Brazil, gabrielachiarotto@yahoo.com.br., Neves LM, Esquisatto MA, do Amaral ME, dos Santos GM, Mendonça FA |
| Jazyk: |
angličtina |
| Zdroj: |
Lasers in medical science [Lasers Med Sci] 2014 Sep; Vol. 29 (5), pp. 1685-93. Date of Electronic Publication: 2014 Apr 13. |
| DOI: |
10.1007/s10103-014-1573-9 |
| Abstrakt: |
This study investigated the effects of 670-nm indium gallium phosphide (InGaP) and 830-nm gallium aluminum arsenide (GaAlAs) laser therapy on second-degree burns induced on the back of Wistar rats. Sixty-three male Wistar rats were anesthetized, and second-degree burns were made on their back. The animals were then divided randomly into three groups: control (C), animals treated with 670-nm InGaP laser (LIn), and animals treated with 830-nm GaAlAs laser (LGa). The wound areas were removed after 2, 6, 10, 14, and 18 days of treatment and submitted to structural and morphometric analysis. The following parameters were studied: total number of granulocytes and fibroblasts, number of newly formed blood vessels, and percentage of birefringent collagen fibers in the repair area. Morphometric analysis showed that different lasers 670-nm InGaP and 830-nm GaAlAs reduced the number of granulocytes and an increase of newly formed vessels in radiated lesions. The 670-nm InGaP laser therapy was more effective in increasing the number of fibroblasts. The different treatments modified the expression of VEGF and TGF-β1, when compared with lesions not irradiated. The different types of light sources showed similar effects, improved the healing of second-degree burns and can help for treating this type of injury. Despite the large number of studies with LLTI application in second-degree burns, there is still divergence about the best irradiation parameters to be used. Further studies are needed for developing a protocol effective in treating this type of injury. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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