An increase of interleukin-33 serum levels after coronary stent implantation is associated with coronary in-stent restenosis.

Autor: Demyanets S; Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria. Electronic address: svitlana.demyanets@meduniwien.ac.at., Tentzeris I; 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria., Jarai R; 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria., Katsaros KM; Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Währinger-Gürtel 18-20, 1090 Vienna, Austria., Farhan S; 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria., Wonnerth A; Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria., Weiss TW; 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria., Wojta J; Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Währinger-Gürtel 18-20, 1090 Vienna, Austria., Speidl WS; Department of Internal Medicine II, Medical University of Vienna, Währinger-Gürtel 18-20, 1090 Vienna, Austria., Huber K; 3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstraße 37, 1160 Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Währinger-Gürtel 18-20, 1090 Vienna, Austria.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2014 Jun; Vol. 67 (2), pp. 65-70. Date of Electronic Publication: 2014 Mar 27.
DOI: 10.1016/j.cyto.2014.02.014
Abstrakt: The study aim was to determine the predictive value of interleukin (IL)-33, a recently described member of the IL-1 family of cytokines, for the development of in-stent restenosis (ISR). IL-33 serum levels were measured in 387 consecutive patients undergoing percutaneous coronary intervention (PCI) of whom 193 had stable angina, 93 non-ST elevation myocardial infarction (NSTEMI), and 101 ST-elevation MI (STEMI), respectively. Blood was taken directly before and 24h after stent implantation. The presence of ISR was initially evaluated by clinical means after six to eight months. When presence of myocardial ischemia was suspected, coronary angiography was performed to confirm the suspected diagnosis of ISR. Clinical ISR was present in total in 34 patients (8.8%). IL-33 was detectable in 185 patients and was below detection limit in 202 patients. In patients with decreased IL-33 (n=95), unchanged or non-detectable levels (n=210) or increased levels of IL-33 after PCI (n=82), ISR-rate was 2.1%, 9.5% and 14.6%, respectively (p<0.05). Accordingly, patients with ISR showed a significant increase of IL-33 upon PCI (p<0.05). This association was independent from clinical presentation and risk factors as well as numbers and type of stents. In patients with both stable and unstable coronary artery disease, an increase of IL-33 serum levels after stent implantation is associated with a higher rate of in-stent restenosis.
(Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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