Protective effect of Euterpe oleracea Mart (açaí) extract on programmed changes in the adult rat offspring caused by maternal protein restriction during pregnancy.

Autor: de Bem GF; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., da Costa CA, de Oliveira PR, Cordeiro VS, Santos IB, de Carvalho LC, Souza MA, Ognibene DT, Daleprane JB, Sousa PJ, Resende AC, de Moura RS
Jazyk: angličtina
Zdroj: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2014 Sep; Vol. 66 (9), pp. 1328-38. Date of Electronic Publication: 2014 Apr 14.
DOI: 10.1111/jphp.12258
Abstrakt: Objectives: This study examined the effect of açaí (Euterpe oleracea Mart.) seed extract (ASE) on cardiovascular and renal alterations in adult offspring, whose mothers were fed a low-protein (LP) diet during pregnancy.
Methods: Four groups of rats were fed: control diet (20% protein); ASE (200 mg/kg per day); and LP (6% protein); LP + ASE (6% protein + ASE) during pregnancy. After weaning, all male offspring were fed a control diet and sacrificed at 4 months old. We evaluated the blood pressure, vascular function, serum and urinary parameters, plasma and kidney oxidative damage, and antioxidant activity and renal structural changes.
Key Findings: Hypertension and the reduced acetylcholine-induced vasodilation in the LP group were prevented by ASE. Serum levels of urea, creatinine and fractional excretion of sodium were increased in LP and reduced in LP + ASE. ASE improved nitrite levels and the superoxide dismutase and glutathione peroxidase activity in LP, with a corresponding decrease of malondialdehyde and protein carbonyl levels. Kidney volume and glomeruli number were reduced and glomerular volume was increased in LP. These renal alterations were prevented by ASE.
Conclusions: Treatment of protein-restricted dams with ASE provides protection from later-life hypertension, oxidative stress, renal functional and structural changes, probably through a vasodilator and antioxidant activity.
(© 2014 Royal Pharmaceutical Society.)
Databáze: MEDLINE
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