Comprehensive evaluation of hemostasis in normal women: impact on the diagnosis of mild bleeding disorders.

Autor:	MacEachern K; Health Science Department, St Lawrence College, Kingston, Ontario, Canada Saint Elizabeth Health Care, Kingston, Ontario, Canada., Kaur H; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Toukh M; Health Science Department, St Lawrence College, Kingston, Ontario, Canada Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Mumal I; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Hamilton A; Health Science Department, St Lawrence College, Kingston, Ontario, Canada Department of anesthesiology and preoperative medicine, Queen's University, Kingston, Ontario, Canada., Scovil S; New Atom Technologies Inc, Kingston, Ontario, Canada., James P; Department of Medicine, Queen's University, Kingston, Ontario, Canada., Elbatarny HS; Health Science Department, St Lawrence College, Kingston, Ontario, Canada Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Othman M; Health Science Department, St Lawrence College, Kingston, Ontario, Canada Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada mothman@sl.on.ca othman@queensu.ca.
Jazyk:	angličtina
Zdroj:	Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2015 Jan; Vol. 21 (1), pp. 72-81. Date of Electronic Publication: 2014 Apr 08.
DOI:	10.1177/1076029614527495
Abstrakt:	Women with mild bleeding disorders (MBDs) pose a diagnostic challenge and menorrhagia, the most common presenting symptom that remains underreported. We tested the hypothesis that screening apparently normal females using general and gynecological bleeding assessment tools and a global hemostatic assay together with platelet aggregation can help predict MBDs. We assessed 47 women using electronic bleeding assessment tools; e-bleeding questionnaire; and e-Pictorial Bleeding Assessment Chart (e-PBAC) based on previously validated methods, thrombelastography (TEG), and platelet aggregation together with basic coagulation testing. Three women had elevated bleeding score with von Willebrand disease diagnosis confirmed in one case and eleven cases had elevated e-PBAC. We report normal ranges for TEG and platelet aggregation in women during the first half of the menstrual cycle and show 23.4% of apparently normal women may have general or heavy menstrual bleeding. This is a prelude to a larger study to determine the validity of bleeding assessment tools in screening for MBDs in women. (© The Author(s) 2014.)
Databáze:	MEDLINE
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