3D movement correction of CT brain perfusion image data of patients with acute ischemic stroke.

Autor: Fahmi F; Department of Biomedical Engineering and Physics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands, f.fahmi@amc.uva.nl., Marquering HA, Borst J, Streekstra GJ, Beenen LF, Niesten JM, Velthuis BK, Majoie CB, vanBavel E
Jazyk: angličtina
Zdroj: Neuroradiology [Neuroradiology] 2014 Jun; Vol. 56 (6), pp. 445-52. Date of Electronic Publication: 2014 Apr 09.
DOI: 10.1007/s00234-014-1358-7
Abstrakt: Introduction: Head movement during CT brain perfusion (CTP) acquisition can deteriorate the accuracy of CTP analysis. Most CTP software packages can only correct in-plane movement and are limited to small ranges. The purpose of this study is to validate a novel 3D correction method for head movement during CTP acquisition.
Methods: Thirty-five CTP datasets that were classified as defective due to head movement were included in this study. All CTP time frames were registered with non-contrast CT data using a 3D rigid registration method. Location and appearance of ischemic area in summary maps derived from original and registered CTP datasets were qualitative compared with follow-up non-contrast CT. A quality score (QS) of 0 to 3 was used to express the degree of agreement. Furthermore, experts compared the quality of both summary maps and assigned the improvement score (IS) of the CTP analysis, ranging from -2 (much worse) to 2 (much better).
Results: Summary maps generated from corrected CTP significantly agreed better with appearance of infarct on follow-up CT with mean QS 2.3 versus mean QS 1.8 for summary maps from original CTP (P = 0.024). In comparison to original CTP data, correction resulted in a quality improvement with average IS 0.8: 17 % worsened (IS = -2, -1), 20 % remained unchanged (IS = 0), and 63 % improved (IS = +1, +2).
Conclusion: The proposed 3D movement correction improves the summary map quality for CTP datasets with severe head movement.
Databáze: MEDLINE
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