Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals.

Autor:	Yaniv Y; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland; Biomedical Engineering Faculty, Technion-IIT, Haifa, Israel. Electronic address: yaely@bm.technion.ac.il., Ahmet I; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Liu J; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland; Cardiovascular Physiology Laboratory, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia., Lyashkov AE; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Guiriba TR; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Okamoto Y; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Ziman BD; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Lakatta EG; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland. Electronic address: lakattae@grc.nia.nih.gov.
Jazyk:	angličtina
Zdroj:	Heart rhythm [Heart Rhythm] 2014 Jul; Vol. 11 (7), pp. 1210-9. Date of Electronic Publication: 2014 Apr 05.
DOI:	10.1016/j.hrthm.2014.03.049
Abstrakt:	Background: A reduction of complexity of heart beating interval variability that is associated with an increased morbidity and mortality in cardiovascular disease states is thought to derive from the balance of sympathetic and parasympathetic neural impulses to the heart. However, rhythmic clocklike behavior intrinsic to pacemaker cells in the sinoatrial node (SAN) drives their beating, even in the absence of autonomic neural input. Objective: To test how this rhythmic clocklike behavior intrinsic to pacemaker cells interacts with autonomic impulses to the heart beating interval variability in vivo. Methods: We analyzed beating interval variability in time and frequency domains and by fractal and entropy analyses: (1) in vivo, when the brain input to the SAN is intact; (2) during autonomic denervation in vivo; (3) in isolated SAN tissue (ie, in which the autonomic neural input is completely absent); (4) in single pacemaker cells isolated from the SAN; and (5) after autonomic receptor stimulation of these cells. Results: Spontaneous beating intervals of pacemaker cells residing in the isolated SAN tissue exhibit fractal-like behavior and have lower approximate entropy compared with those in the intact heart. Isolation of pacemaker cells from SAN tissue, however, leads to a loss in the beating interval order and fractal-like behavior. β-Adrenergic receptor stimulation of isolated pacemaker cells increases intrinsic clock synchronization, decreases their action potential period, and increases system complexity. Conclusions: Both the average beating interval in vivo and beating interval complexity are conferred by the combined effects of clock periodicity intrinsic to pacemaker cells and their response to autonomic neural input. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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