| Autor: |
Luyasu S, Wamelink MM, Galanti L, Dive A |
| Jazyk: |
angličtina |
| Zdroj: |
Acta clinica Belgica [Acta Clin Belg] 2014 Jun; Vol. 69 (3), pp. 221-3. Date of Electronic Publication: 2014 Apr 02. |
| DOI: |
10.1179/2295333714Y.0000000022 |
| Abstrakt: |
High anion gap metabolic acidosis due to pyroglutamic acid (5-oxoproline) is a rare complication of acetaminophen treatment (which depletes glutathione stores) and is often associated with clinically moderate to severe encephalopathy. Acquired 5-oxoprolinase deficiency (penicillins) or the presence of other risk factors of glutathione depletion such as malnutrition or sepsis seems to be necessary for symptoms development. We report the case of a 55-year-old women who developed a symptomatic overproduction of 5-oxoproline during flucloxacillin treatment for severe sepsis while receiving acetaminophen for fever control. Hemodialysis accelerated the clearance of the accumulated organic acid, and was followed by a sustained clinical improvement. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
