| Autor: |
Warltier DC; Department of Pharmacology, Medical College of Wisconsin, Milwaukee 53226., Gross GJ, Brooks HL, Preuss KC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 1988; Vol. 12 Suppl 4, pp. S120-4. |
| DOI: |
10.1097/00005344-198806124-00026 |
| Abstrakt: |
The effect of the new calcium channel blocking agent, nitrendipine, on recovery of contractile function following a 10-min left anterior descending coronary artery occlusion was studied in conscious dogs instrumented with sonomicrometers in the subendocardium of ischemic and normal regions. Nitrendipine (1.0 and 2.5 micrograms/kg/min i.v.) or drug vehicle was administered 30 min prior to the onset of coronary artery occlusion and continued for 30 min following reperfusion accomplished by inflation and deflation of a vascular balloon cuff. Nitrendipine produced a dose-related reduction in arterial pressure and an increase in heart rate and left circumflex coronary blood flow velocity. At 6 h following reperfusion in control dogs (N = 8), segment shortening was significantly reduced from control levels (71 +/- 10% of control). In comparison, dogs pretreated with nitrendipine (3 micrograms/kg/min i.v.) (n = 8) had significantly greater recovery of segment shortening throughout the reperfusion period (102 +/- 10% of control at 6 h following reperfusion). The data demonstrate that pretreatment with the calcium channel blocking agent enhances the recovery of function in postischemic, reperfused, "stunned" myocardium. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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