Antifungal susceptibility patterns of opportunistic fungi in the genera Verruconis and Ochroconis.

Autor:	Seyedmousavi S; Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran S.Seyedmousavi@gmail.com., Samerpitak K; Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands., Rijs AJ; Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands., Melchers WJ; Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands., Mouton JW; Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands., Verweij PE; Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands., de Hoog GS; CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands Peking University Health Science Center, Research Center for Medical Mycology, Beijing, China Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Shanghai Institute of Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, China Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil King Abdullassiz University, Jeddah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Jun; Vol. 58 (6), pp. 3285-92. Date of Electronic Publication: 2014 Mar 31.
DOI:	10.1128/AAC.00002-14
Abstrakt:	Species of Verruconis and species of Ochroconis are dematiaceous fungi generally found in the environment but having the ability to infect humans, dogs, cats, poultry, and fish. This study presents the antifungal susceptibility patterns of these fungi at the species level. Forty strains originating from clinical and environmental sources were phylogenetically identified at the species level by using sequences of the ribosomal DNA internal transcribed spacer (rDNA ITS). In vitro antifungal susceptibility testing was performed against eight antifungals, using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. The geometric mean MICs for amphotericin B (AMB), flucytosine (5FC), fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), and posaconazole (POS) and minimum effective concentrations (MECs) for caspofungin (CAS) and anidulafungin (AFG) across the Ochroconis and Verruconis species were as follows, in increasing order. For Verruconis species, the values (μg/ml) were as follows: AFG, 0.04; POS, 0.25; ITC, 0.37; AMB, 0.50; CAS, 0.65; VRC, 0.96; 5FC, 10.45; and FLC, 47.25. For Ochroconis species, the values (μg/ml) were as follows: AFG, 0.06; POS, 0.11; CAS, 0.67; VRC, 2.76; ITC, 3.94; AMB, 5.68; 5FC, 34.48; and FLC, 61.33. Antifungal susceptibility of Ochroconis and Verruconis was linked with phylogenetic distance and thermotolerance. Echinocandins and POS showed the greatest in vitro activity, providing possible treatment options for Ochroconis and Verruconis infections. (Copyright © 2014, American Society for Microbiology. All Rights Reserved.)
Databáze:	MEDLINE
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