The effect of deep brain stimulation on the speech motor system.
| Autor: | Mücke D, Becker J, Barbe MT, Meister I, Liebhart L, Roettger TB, Dembek T, Timmermann L, Grice M |
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| Jazyk: | angličtina |
| Zdroj: | Journal of speech, language, and hearing research : JSLHR [J Speech Lang Hear Res] 2014 Aug; Vol. 57 (4), pp. 1206-18. |
| DOI: | 10.1044/2014_JSLHR-S-13-0155 |
| Abstrakt: | Purpose: Chronic deep brain stimulation of the nucleus ventralis intermedius is an effective treatment for individuals with medication-resistant essential tremor. However, these individuals report that stimulation has a deleterious effect on their speech. The present study investigates one important factor leading to these effects: the coordination of oral and glottal articulation. Method: Sixteen native-speaking German adults with essential tremor, between 26 and 86 years old, with and without chronic deep brain stimulation of the nucleus ventralis intermedius and 12 healthy, age-matched subjects were recorded performing a fast syllable repetition task (/papapa/, /tatata/, /kakaka/). Syllable duration and voicing-to-syllable ratio as well as parameters related directly to consonant production, voicing during constriction, and frication during constriction were measured. Results: Voicing during constriction was greater in subjects with essential tremor than in controls, indicating a perseveration of voicing into the voiceless consonant. Stimulation led to fewer voiceless intervals (voicing-to-syllable ratio), indicating a reduced degree of glottal abduction during the entire syllable cycle. Stimulation also induced incomplete oral closures (frication during constriction), indicating imprecise oral articulation. Conclusion: The detrimental effect of stimulation on the speech motor system can be quantified using acoustic measures at the subsyllabic level. |
| Databáze: | MEDLINE |
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