Phenolic composition, antioxidant properties, and endothelial cell function of red and white cranberry fruits.

Autor: Tulio AZ Jr; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 6502 South Archer Road, Bedford Park, IL 60501, United States. Electronic address: artemio.tulio@fda.hhs.gov., Jablonski JE; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 6502 South Archer Road, Bedford Park, IL 60501, United States., Jackson LS; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 6502 South Archer Road, Bedford Park, IL 60501, United States., Chang C; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 6502 South Archer Road, Bedford Park, IL 60501, United States; Oak Ridge Institute for Science and Education, Oak Ridge, TN 37830, United States., Edirisinghe I; Institute for Food Safety and Health, Illinois Institute of Technology, 6502 South Archer Road, Bedford Park, IL 60501, United States., Burton-Freeman B; Institute for Food Safety and Health, Illinois Institute of Technology, 6502 South Archer Road, Bedford Park, IL 60501, United States.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2014 Aug 15; Vol. 157, pp. 540-52. Date of Electronic Publication: 2014 Feb 22.
DOI: 10.1016/j.foodchem.2014.02.047
Abstrakt: The effects of phenolic constituents in red cranberry extracts (RCE) and white cranberry extracts (WCE) on the endothelial cell function were investigated. Peonidin-3-O-galactoside, cyanidin-3-O-arabinoside, and cyanidin-3-O-galactoside were the predominant anthocyanins characterized, whereas a procyanidin tetramer was the predominant proanthocyanidin identified. The antioxidant properties of RCE and WCE were not significantly different regardless of antioxidant assays (DPPH, FRAP, and TEAC) used. Both RCE and WCE induced the phosphorylation of Akt in vitro in human umbilical endothelial cells (HUVEC), resulting in the phosphorylation of endothelial nitric oxide synthase, cell migration, and tube formation. The enhanced phosphorylation of PI3/Akt kinase in HUVEC, endothelial cell wound healing, and tube formation elicited by RCE and WCE suggest that overall phenolic constituents rather than individual phenolic compounds within the cranberry matrix may be responsible for these biological effects.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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