Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis.

Autor: Röckmann H; Department of Dermatology/Allergology, University Medical Center Utrecht, Heidelberglaan 100, G 02,124, 3584 Utrecht, CX, The Netherlands. h.rockmann@umcutrecht.nl., van Geel MJ, Knulst AC, Huiskes J, Bruijnzeel-Koomen CA, de Bruin-Weller MS
Jazyk: angličtina
Zdroj: Clinical and translational allergy [Clin Transl Allergy] 2014 Mar 28; Vol. 4 (1), pp. 9. Date of Electronic Publication: 2014 Mar 28.
DOI: 10.1186/2045-7022-4-9
Abstrakt: Background: Limited data are available on the frequency of IgE mediated food sensitization and food allergy (FA) in adults with atopic dermatitis (AD).
Objective: We investigated the pattern of food sensitization in adults with AD in relation to AD severity using multiplexed allergen microarray.
Methods: 211 adult patients referred between January 2010-July 2011 for evaluation of AD were unselectively included. Severity of AD was determined by therapy intensity, SASSAD-skin-score and sTARC levels. Allergen specific sIgE levels were measured by ImmunoCAP ISAC® microarray. FA was defined as convincing history taken by physician and sensitization to the corresponding allergen.
Results: Sensitization to food was found in 74.4% of the AD patients, 54% had a positive history of FA and 20.4% asymptomatic sensitization. There was no association between severity of AD and frequency of food sensitization or history of FA.Sensitization to PR-10 related food allergens occurred most frequently (63.5%) and was independent from AD severity. Correspondingly, pollen-food syndrome accounted for most of the FA, being also independent from AD severity. Of all plant food allergens only sensitization to nAra h 1 was significantly more frequent in patients with severe AD. In the total group 75 (35.5%) patients with AD showed sensitization to any animal food allergen. The percentage was significantly higher in patients with severe AD (51.4%) compared to patients with mild/moderate AD (27.7%). Sensitization to cow's milk allergens, in particular to nBos d lactoferrin, was more frequent in severe AD patients.
Conclusion: AD was frequently associated with food sensitization. The percentage of sensitization to animal food allergens was significantly higher in severe AD patients.
Databáze: MEDLINE
Externí odkaz: