Is symmetric dimethylarginine a sensitive biomarker of subclinical kidney injury in children born with low birth weight?

Autor: Protas PT; Department of Pediatric Nephrology, Medical University of Bialystok , Bialystok , Poland., Tenderenda-Banasiuk E, Taranta-Janusz K, Fiłonowicz R, Zając M, Wasilewska A
Jazyk: angličtina
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2014 May; Vol. 19 (3), pp. 231-5. Date of Electronic Publication: 2014 Mar 28.
DOI: 10.3109/1354750X.2014.899393
Abstrakt: Objective: The aim of this study was to investigate if Symmetric Dimethylarginine (SDMA) is a sensitive biomarker of renal function and may predict subclinical kidney injury in low birth weight (LBW) children.
Methods: We studied 68 LBW children and 20 children as reference group. An enzyme-linked immunosorbent assay was used to measure serum SDMA and Cystatin C (Cys C).
Results: SDMA levels were higher in study groups compared to reference groups. There was a strong correlation between SDMA and Cys C, also SDMA negatively correlated with eGFR.
Conclusion: Elevated SDMA concentration may play an important role in pathogenesis of chronic kidney disease.
Databáze: MEDLINE
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