| Autor: |
Dugo M, Pasi A, Gatti PL, Mastrosimone S, Laurino L, Barberio G, Farneti F, Facchini C, Maresca MC |
| Jazyk: |
italština |
| Zdroj: |
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2014 Jan-Feb; Vol. 31 (1). |
| Abstrakt: |
Goodpasture's disease (GD) is an uncommon and severe autoimmune disorder caused by circulating autoantibodies directed against the glomerular basement membrane cross-reacting with the alveolar basement membrane. GD is clinically characterized by rapidly progressive glomerulonephritis, often associated with pulmonary hemorrhage representing a nephrological emergency. We present the clinical features of 9 cases, diagnosed in 1997-2012, in our Renal Unit. Contrary to previous reports, we found a predominance of GD in females and we observed unusual clinical patterns, such as the association with renal vein thrombosis in a pregnant patient, thrombosis of the pulmonary arteries and a late isolated recurrence of alveolitis. In dialysis-dependent patients, renal transplantation can represent an available treatment option. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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