Heart transplantation in pediatric and congenital heart disease: a single-center experience.
| Autor: | Rungan S; Green Lane Pediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand., Finucane K, Gentles T, Gibbs HC, Hu R, Ruygrok PN |
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| Jazyk: | angličtina |
| Zdroj: | World journal for pediatric & congenital heart surgery [World J Pediatr Congenit Heart Surg] 2014 Apr; Vol. 5 (2), pp. 200-5. |
| DOI: | 10.1177/2150135113519456 |
| Abstrakt: | Purpose: To describe the indications and outcomes for pediatric patients and patients with congenital heart disease (CHD) undergoing heart transplantation (HT) in New Zealand. Methods: A retrospective audit of 253 patients who underwent HT from 1987 to end 2012 was undertaken. Thirty-seven patients were subdivided into two groups, those aged <18 years--pediatric heart disease (PHD) and those with CHD. Six patients aged <18 years were included in both the analyses. Demographic and clinical information were collected and outcomes established. Results: Overall actuarial survival of 37 patients with PHD or CHD was 92% at one year, 85% at five years, and 52% at ten years. The PHD group comprised 22 (8.7%) patients, median age 14 years (range 6-17), 14 (64%) male, with cardiomyopathy in 13, CHD in 6, and rheumatic heart disease in 3. At follow-up, 11 patients had died. Actuarial survival was 91% at one year and 79% at five years. Of the four patients with a mechanical assist device to bridge, three were transplanted and alive at follow-up. The CHD group comprised 21 (8.3%) patients, median age 25 years (range 6-48) and 19 (90%) were male. At follow-up, three patients had died. Actuarial survival was 95% at one year, 94% at five years, and 85% at ten years. All five patients with pre-HT Fontan circulation were alive a median of eight years following HT. Conclusion: Heart transplantation for carefully selected pediatric patients and patients with CHD can be successfully performed with favorable outcomes in a geographically isolated unit. |
| Databáze: | MEDLINE |
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