New polyfunctional imidazo[4,5-C]pyridine motifs: synthesis, crystal studies, docking studies and antimicrobial evaluation.

Autor: Jose G; P.G. Department of Chemistry, Jain University, 127/2, Bull Temple Road, Chamarajpet, Bangalore 560026, India., Suresha Kumara TH; P.G. Department of Chemistry, Jain University, 127/2, Bull Temple Road, Chamarajpet, Bangalore 560026, India; Department of Chemistry, U.B.D.T. College of Engineering, Davangere, Karnataka 577004, India. Electronic address: suresha.kumara@rediffmail.com., Nagendrappa G; P.G. Department of Chemistry, Jain University, 127/2, Bull Temple Road, Chamarajpet, Bangalore 560026, India., Sowmya HB; P.G. Department of Chemistry, Jain University, 127/2, Bull Temple Road, Chamarajpet, Bangalore 560026, India., Jasinski JP; Department of Chemistry, Keene State College, Keene, N.H. 03435-2001, USA., Millikan SP; Department of Chemistry, Keene State College, Keene, N.H. 03435-2001, USA., Chandrika N; P.G. Department of Chemistry, Jain University, 127/2, Bull Temple Road, Chamarajpet, Bangalore 560026, India., More SS; P.G. Department of Biochemistry, C.P.G.S., Jain University, Jayanagar 3rd block, Bangalore 560011, India., Harish BG; Department of Biotechnology, M.S. Ramaiah Institute of Technology, Bangalore 560054, India.
Jazyk: angličtina
Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2014 Apr 22; Vol. 77, pp. 288-97. Date of Electronic Publication: 2014 Mar 11.
DOI: 10.1016/j.ejmech.2014.03.019
Abstrakt: New antimicrobial agents, imidazo[4,5-c]pyridine derivatives have been synthesized. We have developed a new synthetic protocol for the final reaction, an efficient microwave-assisted synthesis of imidazo[4,5-c]pyridines from substituted 3,4-diaminopyridine and carboxylic acids in presence of DBU mediated by T3P. The chemical structures of the new compounds were characterized by IR, (1)H NMR, (13)C NMR, mass spectral analysis and elemental analysis. In addition, single crystal X-ray diffraction has also been recorded for compound 9c. The in vitro antimicrobial activities of the compounds were conducted against various Gram-negative, Gram-positive bacteria and fungi. Amongst the tested compounds 9c, 9e, 9g, 9k and 9l displayed promising antimicrobial activity. The molecular docking of GlcN-6-P synthase with newly synthesized compounds was carried out.
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Databáze: MEDLINE
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