Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations.

Autor:	Song HK; Division of Cardiothoracic Surgery, Oregon Health & Science University, Portland, Oregon. Electronic address: songh@ohsu.edu., von Heymann C; Department of Anaesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany., Jespersen CM; Safety Surveillance, Global Safety, Novo Nordisk, Bagsværd, Denmark., Karkouti K; Department of Anesthesia and Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada., Korte W; Center for Laboratory Medicine, St Gallen, Switzerland., Levy JH; Department of Anesthesiology and Critical Care, Duke University School of Medicine, Durham, North Carolina., Ranucci M; Department of Cardiothoracic-Vascular Anesthesia and Intensive Care Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy., Saugstrup T; Biostatistics, Novo Nordisk A/S, Søborg, Denmark., Sellke FW; Department of Surgery, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island.
Jazyk:	angličtina
Zdroj:	The Annals of thoracic surgery [Ann Thorac Surg] 2014 May; Vol. 97 (5), pp. 1630-5. Date of Electronic Publication: 2014 Mar 19.
DOI:	10.1016/j.athoracsur.2013.12.025
Abstrakt:	Background: Perioperative red blood cell transfusion is associated with adverse outcomes after cardiac operations. Although restrictive transfusion protocols have been developed, their safety and efficacy are not well demonstrated, and considerable variation in transfusion practice persists. We report our experience with a restrictive transfusion protocol. Methods: We analyzed the outcomes in 409 patients undergoing cardiac operations enrolled in a trial conducted at 30 centers worldwide. Blood products were administered on the basis of a transfusion algorithm applied across all centers, with a restrictive transfusion trigger of hemoglobin less than or equal to 6 g/dL. Transfusion was acceptable but not mandatory for hemoglobin 6 to 8 g/dL. For hemoglobin 8 to 10 g/dL, transfusion was acceptable only with evidence for end-organ ischemia. Results: The patient population was moderately complex, with 20.5% having combined procedures and 29.6% having nonelective operations. The mean EuroSCORE for the population was 4.3, which predicted a substantial incidence of morbidity and mortality. Actual outcomes were excellent, with observed mortality of 0.49% and rates of cerebrovascular accident, myocardial infarction, and acute renal failure 1.2%, 6.1%, and 0.98%, respectively. The frequency of red blood cell transfusion was 33.7%, which varied significantly by center. Most transfusions (71.9%) were administered for hemoglobin 6 to 8 g/dL; 21.4% were administered for hemoglobin 8 to 10 g/dL with evidence for end-organ ischemia; 65.0% of patients avoided allogeneic transfusion altogether. Conclusions: A restrictive transfusion protocol can be safely applied in the care of moderate-risk patients undergoing cardiac operations. This strategy has significant potential to reduce transfusion and resource utilization in these patients, standardize transfusion practices across institutions, and increase the safety of cardiac operations. (Copyright © 2014 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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