| Autor: |
Colegate SM; Poisonous Plant Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture , 1150 East 1400 North, Logan, Utah 84341, United States., Welsh SL, Gardner DR, Betz JM, Panter KE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of agricultural and food chemistry [J Agric Food Chem] 2014 Jul 30; Vol. 62 (30), pp. 7382-92. Date of Electronic Publication: 2014 Mar 28. |
| DOI: |
10.1021/jf500425v |
| Abstrakt: |
Species of the Amsinckia genus (Boraginaceae) are known to produce potentially hepato-, pneumo-, and/or genotoxic dehydropyrrolizidine alkaloids. However, the taxonomic differentiation of Amsinckia species can be very subtle and there seems to be marked differences in toxicity toward grazing livestock. Methanol extracts of mass-limited leaf samples from herbarium specimens (collected from 1899 to 2013) of 10 Amsinckia species and one variety were analyzed using HPLC-esi(+)MS and MS/MS for the presence of potentially toxic dehydropyrrolizidine alkaloids and/or their N-oxides. Dehydropyrrolizidine alkaloids were detected in all specimens examined ranging from about 1 to 4000 μg/g of plant. Usually occurring mainly as their N-oxides, the predominant alkaloids were the epimeric lycopsamine and intermedine. Also sometimes observed in higher concentrations were the 3'- and 7-acetyl derivatives of lycopsamine/intermedine and their N-oxides. Within a designated species, an inconsistent profile was often observed that may be due to natural variation, taxonomic misassignment, or nonuniform degradation due to plant collection and storage differences. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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