Effects of aging on the plasma levels of nesfatin-1 and adiponectin.

Autor:	Li JB; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan ; Department of Clinical Psychiatry, The Second People's Hospital of Wuhu Affiliated to Wannan Medical College, Wuhu, Anhui 241001, P.R. China., Nishida M; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Kaimoto K; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Asakawa A; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Chaolu H; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Cheng KC; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Li YX; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Terashi M; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Koyama KI; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Amitani H; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Sakoguchi T; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Ushikai M; Department of Human and Environmental Sciences, Division of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Ikeda S; Department of Neuromusculoskeletal Disorders, Division of Rehabilitation and Physical Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Aoyama K; Department of Human and Environmental Sciences, Division of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Horiuchi M; Department of Human and Environmental Sciences, Division of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan., Li JZ; College of Psychology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China., Inui A; Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan.
Jazyk:	angličtina
Zdroj:	Biomedical reports [Biomed Rep] 2014 Jan; Vol. 2 (1), pp. 152-156. Date of Electronic Publication: 2013 Nov 22.
DOI:	10.3892/br.2013.206
Abstrakt:	Gastric and adipose tissue secrete a number of hormones that are involved in energy metabolism. The biological functions of these hormones, including their effects on aging, are currently under investigation. Adiponectin was shown to be directly involved in appetite and the control of body weight. However, the effects of aging of nesfatin-1, an appetite-suppressing peptide that was recently identified, have not yet been fully elucidated. The aim of this study was to determine the effects of aging on the plasma levels of nesfatin-1 and adiponectin. Our results demonstrated no significant differences in the nesfatin-1 plasma levels among three age groups (2, 6 and 24 months) of female BALB/c mice. The plasma nesfatin-1 levels/visceral fat (VF) ratio in the 24-month-old mice was significantly lower compared to that in the 2- and 6-month-old mice. In addition, there were no significant differences in the plasma adiponectin levels among the three age groups. The plasma adiponectin levels/VF ratio in the 24-month-old mice was significantly lower compared to that in the 2- and 6-month-old mice. In conclusion, there were no age-related changes in the plasma levels of nesfatin-1 and adiponectin, although the ratio of plasma levels of nesfatin-1 and adiponectin per VF was decreased with advancing age. Our results indicated that nesfatin-1 and adiponectin may be involved in controlling energy balance during aging.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF