Rectal tumour volume (GTV) delineation using T2-weighted and diffusion-weighted MRI: Implications for radiotherapy planning.

Autor: Regini F; Department of Radiology,Guy's & St Thomas' NHS Foundation Trust, London, UK; Department of Experimental and Clinical Biomedical Sciences - Radiodiagnostic Unit 2 - University of Florence- Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy. Electronic address: francesco.regini@yahoo.it., Gourtsoyianni S; Department of Radiology,Guy's & St Thomas' NHS Foundation Trust, London, UK; Division of Imaging Sciences & Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, UK. Electronic address: sofia.gourtsoyianni@gstt.nhs.uk., Cardoso De Melo R; Department of Radiology,Guy's & St Thomas' NHS Foundation Trust, London, UK. Electronic address: rafaelgoiein@gmail.com., Charles-Edwards GD; Division of Imaging Sciences & Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, UK; Medical Physics, Guy's & St Thomas' NHS Foundation Trust, London, UK. Electronic address: geoff.charles-edwards@kcl.ac.uk., Griffin N; Department of Radiology,Guy's & St Thomas' NHS Foundation Trust, London, UK; Division of Imaging Sciences & Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, UK. Electronic address: nyree.griffin@gatt.nhs.uk., Parikh J; Department of Radiology,Guy's & St Thomas' NHS Foundation Trust, London, UK. Electronic address: jyoti.parikh@gstt.nhs.uk., Rottenberg G; Department of Radiology,Guy's & St Thomas' NHS Foundation Trust, London, UK. Electronic address: giles.rottenberg@gstt.nhs.uk., Leslie M; Department of Clinical Oncology, Guy's & St Thomas' NHS Foundation Trust, London, UK. Electronic address: martin.leslie@gstt.nhs.uk., Gaya A; Department of Clinical Oncology, Guy's & St Thomas' NHS Foundation Trust, London, UK. Electronic address: andrew.gaya@gstt.nhs.uk., Goh V; Department of Radiology,Guy's & St Thomas' NHS Foundation Trust, London, UK; Division of Imaging Sciences & Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, UK. Electronic address: vicky.goh@kcl.ac.uk.
Jazyk: angličtina
Zdroj: European journal of radiology [Eur J Radiol] 2014 May; Vol. 83 (5), pp. 768-72. Date of Electronic Publication: 2014 Feb 25.
DOI: 10.1016/j.ejrad.2014.02.007
Abstrakt: Purpose: To compare the rectal tumour gross target volume (GTV) delineated on T2 weighted (T2W MRI) and diffusion weighted MRI (DWI) images by two different observers and to assess if agreement is improved by DWI.
Material and Methods: 27 consecutive patients (15 male, range 27.1-88.8 years, mean 66.9 years) underwent 1.5T MRI prior to chemoradiation (45Gy in 25 fractions; oral capecitabine 850mg/m(2)), including axial T2W MRI (TR=6600ms, TE=90ms) and DWI (TR=3000ms, TE=77ms, b=0, 100, 800s/mm(2)). 3D tumour volume (cm(3)) was measured by volume of interest (VOI) analysis by two independent readers for the T2W MRI and b800 DWI axial images, and the T2W MRI and DWI volumes compared using Mann-Whitney test. Observer agreement was assessed using Bland-Altman statistics. Significance was at 5%.
Results: Artefacts precluded DWI analysis in 1 patient. In the remaining 26 patients evaluated, median (range) T2W MRI MRI and DWI (b=800s/mm(2)) 3D GTVin cm(3) were 33.97 (4.44-199.8) and 31.38 (2.43-228), respectively, for Reader One and 43.78 (7.57-267.7) and 42.45 (3.68-251) for Reader Two. T2W MRI GTVs were slightly larger but not statistically different from DWI volumes: p=0.52 Reader One; p=0.92 Reader Two. Interobserver mean difference (95% limits of agreement) for T2W MRI and DWI GTVs were -9.84 (-54.96 to +35.28) cm(3) and -14.79 (-54.01 to +24.43) cm(3) respectively.
Conclusion: Smaller DWI volumes may result from better tumour conspicuity but overall observer agreement is not improved by DWI.
(Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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