| Autor: |
Nazari QA; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-Ku, Kyoto 606-8501, Japan. tkume@pharm.kyoto-u.ac.jp., Takada-Takatori Y, Hashimoto T, Imaizumi A, Izumi Y, Akaike A, Kume T |
| Jazyk: |
angličtina |
| Zdroj: |
Food & function [Food Funct] 2014 May; Vol. 5 (5), pp. 984-9. |
| DOI: |
10.1039/c4fo00009a |
| Abstrakt: |
Curcumin, a polyphenolic compound has several pharmacological activities, such as anticancer, anti-inflammatory and antioxidant effects. However, curcumin shows poor oral bioavailability. The purpose of this study was to investigate the protective effects of highly bioavailable curcumin, Theracurmin(®), and curcumin, against sodium nitroprusside (SNP)-induced oxidative damage in mice brain. Intrastriatal microinjection of Theracurmin(®) or curcumin with SNP significantly protected against SNP-induced brain damage and motor dysfunction. Oral administration of Theracurmin(®) (1 and 3 g kg(-1), containing 100 and 300 mg kg(-1) curcumin, respectively) significantly protected against SNP-induced brain damage and motor dysfunction. However, oral administration of 300 mg kg(-1) curcumin did not protect against motor dysfunction induced by SNP. These results suggest that curcumin and Theracurmin(®) have protective effects against SNP-induced oxidative damage. Moreover, oral administration of Theracurmin(®), had more potency in protecting against brain damage, suggesting a higher bioavailability of Theracurmin(®) following oral administration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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