The intestinal metabolome: an intersection between microbiota and host.

Autor:	Ursell LK; Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado., Haiser HJ; Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts., Van Treuren W; Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado., Garg N; Departments of Pharmacology, Chemistry, and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California., Reddivari L; Department of Plant Science, Pennsylvania State University, University Park, Pennsylvania., Vanamala J; Department of Food Science, Pennsylvania State University, University Park, Pennsylvania., Dorrestein PC; Departments of Pharmacology, Chemistry, and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California., Turnbaugh PJ; Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts., Knight R; Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado; BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado; Howard Hughes Medical Institute, Boulder, Colorado. Electronic address: rob.knight@colorado.edu.
Jazyk:	angličtina
Zdroj:	Gastroenterology [Gastroenterology] 2014 May; Vol. 146 (6), pp. 1470-6. Date of Electronic Publication: 2014 Mar 11.
DOI:	10.1053/j.gastro.2014.03.001
Abstrakt:	Recent advances that allow us to collect more data on DNA sequences and metabolites have increased our understanding of connections between the intestinal microbiota and metabolites at a whole-systems level. We can also now better study the effects of specific microbes on specific metabolites. Here, we review how the microbiota determines levels of specific metabolites, how the metabolite profile develops in infants, and prospects for assessing a person's physiological state based on their microbes and/or metabolites. Although data acquisition technologies have improved, the computational challenges in integrating data from multiple levels remain formidable; developments in this area will significantly improve our ability to interpret current and future data sets. (Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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