Low intensity resistance training improves systolic function and cardiovascular autonomic control in diabetic rats.

Autor: Mostarda CT; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil., Rodrigues B; Human Movement Laboratory, Universidade São Judas Tadeu UST, São Paulo/SP, Brazil., de Moraes OA; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil; Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo/SP, Brazil., Moraes-Silva IC; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil., Arruda PB; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil., Cardoso R; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil., Scapini KB; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil., Dos Santos F; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil., De Angelis K; Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo/SP, Brazil., Irigoyen MC; Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil. Electronic address: hipirigoyen@incor.usp.br.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2014 May-Jun; Vol. 28 (3), pp. 273-8. Date of Electronic Publication: 2013 Dec 27.
DOI: 10.1016/j.jdiacomp.2013.12.005
Abstrakt: Aims: We evaluated the effects of low intensity resistance training (RT) on left ventricular (LV) function, baroreflex sensitivity (BRS), and cardiovascular autonomic control of streptozotocin-induced diabetic rats.
Methods: Male Wistar rats were divided into (n=8 each group): sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Trained groups underwent low intensity RT (40%-50% 1 repetition maximum) for 10 weeks. Echocardiographic evaluation, arterial pressure (AP), heart rate (HR), BRS, and autonomic measurements were performed.
Results: Diabetes induced an increase in glycemia and a reduction in body weight in diabetics when compared with control animals. Diabetic rats displayed cardiac dysfunction, reduced systolic AP and HR, impaired BRS and autonomic derangement when compared to control rats. RT improved ejection fraction (SD: 68%±1.3% vs. TD: 75%±3.0%) and velocity of circumferential fiber shortening (SD: 0.32±0.02 vs. TD: 0.40±0.01 circ/seg.10(-4)). Trained diabetic rats presented increased AP (+10.2%), HR (+10.4%), and BRS after RT protocol.
Conclusions: Low intensity RT induced an increase in systolic function in diabetic rats. This may be due to positive LV remodeling and BRS improvement, which may have played an important role in the attenuation of hemodynamic impairment and cardiac autonomic neuropathy in streptozotocin-diabetic rats.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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