A direct access to bioactive fused N-heterocyclic acetic acid derivatives.

Autor: Adepu R; Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. manojitpal@rediffmail.com., Rajitha A, Ahuja D, Sharma AK, Ramudu B, Kapavarapu R, Parsa KV, Pal M
Jazyk: angličtina
Zdroj: Organic & biomolecular chemistry [Org Biomol Chem] 2014 Apr 28; Vol. 12 (16), pp. 2514-8.
DOI: 10.1039/c3ob42535e
Abstrakt: A Cu-catalyzed new sequence involving the Ullmann type intermolecular C-C followed by an intramolecular C-N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4.
Databáze: MEDLINE