| Autor: |
Koldin II, Treshchalina EM, Sharovskaia IuIu, Dubovaia TK, Kobliakov VA |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 2013; Vol. 55 (5), pp. 328-32. |
| Abstrakt: |
To study the tumour-promotion activity of cell environment the transformed embryonic rat fibroblasts (clone CL-1-1) were transfect to immunodeficient mice then the cells of the formed tumour were cultivated (clone CL-1-1). The cells before and after transplantation were compared by morphology, proliferation activity and gap junction intracellular communications. The clone CL-1 cells proliferated much faster than clone CL-1 cells. The CL-1-1 cells had changed morphology structure and unlike CL-1 the contract inhibition was absent in CL-1-1. The number of CL-1 cells in phase G1 was significantly greater than that of CL-1-1 cells, while the number of CL-1-1 cells in G2/M phases was much more the number of CL-1 cells. The activity of gap junction intercellular communications in both cell types was near the same. It was concluded that cell microenvironment act as a tumour-promoter and tumour progression factor in the case of cell transplantation to immunodeficient mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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