| Abstrakt: |
The aim of the study was to examine the reorganization of left ventricular myocardium (LVM) in ovariectomized rats with experimental heart failure (EHF) as affected by melatonin administration. Rat LVM was studied using the methods of light microscopy, immunocytochemistry and morphometry. At day 14 of EHF, marked heteromorphism of contractile cardiomyocytes (CMC), signs of dystrophy, overcontraction and damage of muscle fibers, karyopyknosis, paranuclear edema, local sarcoplasm destruction were detected together with CMC showing signs of apoptosis. At day 28 after EHF modeling, a further increase in the number of CMC with significant changes in the morphological and tinctorial properties was found as well as the cells with signs of apoptosis. In rats given melatonin for 14 days, there was a regression of pathological changes, with the decrease in the hypertrophy of CMC and their nuclei, reduction of the number of CMC with the signs of apoptosis. Cardioprotective effect of melatonin on LVM of ovariectomized rats with EHF is discussed. |
