β-human chorionic gonadotropin assay in vaginal washing fluid for the accurate diagnosis of premature rupture of membranes during late pregnancy.

Autor:	Temel O; Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, İstanbul, Turkey., Cöğendez E; Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, İstanbul, Turkey., Selçuk S; Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, İstanbul, Turkey., Asoğlu MR; The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America., Kaya E; Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, İstanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of the Turkish German Gynecological Association [J Turk Ger Gynecol Assoc] 2013 Dec 01; Vol. 14 (4), pp. 201-4. Date of Electronic Publication: 2013 Dec 01 (Print Publication: 2013).
DOI:	10.5152/jtgga.2013.65624
Abstrakt:	Objective: To determine whether the measurement of beta-human chorionic gonadotropin (β-hCG) levels in vaginal fluid is useful for the diagnosis of premature rupture of membranes (PROM). Material and Methods: A total of 92 pregnant women between 24 and 40 weeks gestation participated in this study. The patients with fluid leaking from the vagina were designated Group 1, the patients with no fluid leaking from the vagina were Group 2, and those with a suspicion of fluid leaking from the vagina were classified as Group 3. Irrigating the posterior vaginal fornix with 5 mL sterile saline was used to measure β-hCG levels of the patients. Receiver operator curve (ROC) analysis was used to determine the cut-off value for a positive diagnosis. Results: The β-hCG levels of vaginal fluid were measured as 20.5±25.0 mIU/mL, 254.6±346.8 mIU/mL, and 74.3±100.8 mIU/mL in Group 1, Group 2, and Group 3, respectively. Vaginal β-hCG level was higher statistically significantly in Group 2 than Group 1 and 3 (p<0.001). 100 mIU/mL was accepted as a cut-off value by using the receiver operating characteristic curve. According to 100 mIU/mL, sensitivity, specificity, positive predictive and negative predictive values were calculated as 71.2, 100, 100, and 65.1%, respectively. Conclusion: The study showed that the measurement of β-hCG level in vaginal washing fluid is an efficient and easy diagnostic test for predicting the amount of fluid leaking from the vagina. However, due to the low negative predictive value of the test, it would not be convenient in daily practice.
Databáze:	MEDLINE
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