Chronic hepatitis B prevalence among children and mothers: results from a nationwide, population-based survey in Lao People's Democratic Republic.

Autor: Xeuatvongsa A; National Immunization Program, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Komada K; Bureau of International Cooperation, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan., Kitamura T; Bureau of International Cooperation, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan., Vongphrachanh P; National Center for Laboratory and Epidemiology, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Pathammavong C; National Immunization Program, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Phounphenghak K; National Immunization Program, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Sisouk T; National Center for Laboratory and Epidemiology, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Phonekeo D; National Center for Laboratory and Epidemiology, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Sengkeopaseuth B; National Center for Laboratory and Epidemiology, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Som-Oulay V; National Center for Laboratory and Epidemiology, Ministry of Health, Lao PDR, Simeuang Road, Vientiane, Lao PDR., Ishii K; Department of Virology II, National Institute of Infectious Diseases, Musashi-murayama, Tokyo, Japan., Wakita T; Department of Virology II, National Institute of Infectious Diseases, Musashi-murayama, Tokyo, Japan., Sugiyama M; Hepatology Research Center, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan., Hachiya M; Bureau of International Cooperation, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2014 Feb 28; Vol. 9 (2), pp. e88829. Date of Electronic Publication: 2014 Feb 28 (Print Publication: 2014).
DOI: 10.1371/journal.pone.0088829
Abstrakt: Background: Hepatitis B is regarded as a serious public health issue in Lao People's Democratic Republic (Lao PDR), a Southeast Asian country. However, disease epidemiology among the general population is not well known, and thus a nationwide cross-sectional survey for hepatitis B surface antigen (HBsAg) prevalence in children and their mothers was conducted.
Methods and Findings: We applied three-stage cluster sampling using probability proportionate to size. After randomly selecting child (5 to 9 years old) and mother (15 to 45 years old) pairs from the selected villages, questionnaires and HBsAg rapid tests were conducted. Data from 965 child and mother pairs were analyzed. Multivariate logistic regression analyses were used to investigate the independent association of individual background characteristics for the odds of being HBsAg positive. In total, 17 children and 27 mothers were HBsAg positive. HBsAg prevalence was estimated to be 1.7% (95% confidence interval: 0.8%-2.6%) in children, and 2.9% (95% confidence interval: 1.7%-4.2%) in their mothers after taking sampling design and weight of each sample into account. Mother's infection status was positively associated with HBsAg positivity in children (p<0.001), whereas other potential risk factors, such as ethnicity, proximity to health centers, and history of surgery, were not. There were no significant associations between mother's HBsAg status and history of surgery, and other sociodemographic factors.
Conclusions: Despite the slow implementation of the hepatitis B vaccination program, HBsAg prevalence among children and their mothers was not high in Lao PDR compared to reports from neighboring countries. The reasons for the differences in prevalence among these countries are unclear. We recommend that prevalence surveys be conducted in populations born before and after the implementation of a hepatitis B vaccination program to better understand the epidemiology of hepatitis B.
Databáze: MEDLINE
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