Transposable elements and psychiatric disorders.

Autor: Guffanti G; Department of Psychiatry, Columbia University, New York, New York., Gaudi S, Fallon JH, Sobell J, Potkin SG, Pato C, Macciardi F
Jazyk: angličtina
Zdroj: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2014 Apr; Vol. 165B (3), pp. 201-16. Date of Electronic Publication: 2014 Feb 28.
DOI: 10.1002/ajmg.b.32225
Abstrakt: Transposable Elements (TEs) or transposons are low-complexity elements (e.g., LINEs, SINEs, SVAs, and HERVs) that make up to two-thirds of the human genome. There is mounting evidence that TEs play an essential role in genomic architecture and regulation related to both normal function and disease states. Recently, the identification of active TEs in several different human brain regions suggests that TEs play a role in normal brain development and adult physiology and quite possibly in psychiatric disorders. TEs have been implicated in hemophilia, neurofibromatosis, and cancer. With the advent of next-generation whole-genome sequencing approaches, our understanding of the relationship between TEs and psychiatric disorders will greatly improve. We will review the biology of TEs and early evidence for TE involvement in psychiatric disorders.
(© 2014 Wiley Periodicals, Inc.)
Databáze: MEDLINE