| Autor: |
Sully EK; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA., Whaley KJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Pauly MH, Velasco J, Hiatt E, Morton J, Swope K, Roy CJ, Zeitlin L, Mantis NJ |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2014 May; Vol. 21 (5), pp. 777-82. Date of Electronic Publication: 2014 Feb 26. |
| DOI: |
10.1128/CVI.00003-14 |
| Abstrakt: |
Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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