Malignant hyperthermia in Brazil: analysis of hotline activity in 2009.

Autor:	da Silva HC; MD; PhD; Professor; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp). Electronic address: halsilva@uol.com.br., Almeida Cdos S; RN; MSc Student, Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Brandão JC; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Nogueira e Silva CA; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., de Lorenzo ME; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Ferreira CB; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Resende AH; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Barreira SR; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., de Almeida PA; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Ferraro LH; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Takeda A; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., de Oliveira KF; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Lelis TG; MD; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Hortense A; MD; MSc; Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Perez MV; MD; PhD, Department of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp., Schmidt B; MD; PhD, Professor, Division of Neuromuscular Diseases, Department of Neurology, Escola Paulista de Medicina, Unifesp., Oliveira AS; MD; PhD, Professor, Division of Neuromuscular Diseases, Department of Neurology, Escola Paulista de Medicina, Unifesp., do Amaral JL; MD, PhD, Full Professor of Anesthesiology, Pain and Intensive Care, Escola Paulista de Medicina, Unifesp.
Jazyk:	angličtina
Zdroj:	Brazilian journal of anesthesiology (Elsevier) [Braz J Anesthesiol] 2013 Jan; Vol. 63 (1), pp. 13-9. Date of Electronic Publication: 2013 Aug 07.
DOI:	10.1016/j.bjane.2012.03.001
Abstrakt:	Background and Objectives: Malignant hyperthermia (MH) is a pharmacogenetic disease that causes abnormal hypermetabolic reaction to halogenated anesthetics and/or depolarizing muscle relaxants. In Brazil, there is a hotline telephone service for MH since 1991, available 24 hours a day in São Paulo. This article analyzes the activity of the Brazilian hotline service for MH in 2009. Methods: Prospective analysis of all phone calls made to the Brazilian hotline service for MH from January to December 2009. Results: Twenty-two phone calls were received: 21 from the South/Southeast region of Brazil and one from the North region. Fifteen calls were requests for general information about MH. Seven were about suspected MH acute episodes, two of which were not considered as MH. In five episodes compatible with MH, all patients received halogenated volatile anesthetics (2, isoflurane; 3, sevoflurane) and one also used succinylcholine; there were four men and one woman, with a mean age of 18 years (2-27). The problems described in the five MH episodes were tachycardia (5), increased expired carbon dioxide (4), hyperthermia (3), acidemia (1), rhabdomyolysis (1), and myoglobinuria (1). One patient received dantrolene. All five patients with MH episodes were follow-up in the intensive care unit and recovered without sequelae. Susceptibility to MH was later confirmed in two patients by in vitro muscle contracture test. Conclusions: The number of calls per year in the Brazilian hotline service for MH is still low. The characteristics of MH episode were similar to those reported in other countries. The knowledge of MH in Brazil needs to be increased. (Copyright © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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