| Autor: |
Höhn TJ; Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany., Grune T; Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Redox biology [Redox Biol] 2014 Jan 14; Vol. 2, pp. 388-94. Date of Electronic Publication: 2014 Jan 14 (Print Publication: 2014). |
| DOI: |
10.1016/j.redox.2013.12.029 |
| Abstrakt: |
Here, we review shortly the current knowledge on the regulation of the proteasomal system during and after oxidative stress. After addressing the components of the proteasomal system and the degradation of oxidatively damaged proteins in part I and II of this series, we address here which changes in activity undergo the proteasome and the ubiquitin-proteasomal system itself under oxidative conditions. While several components of the proteasomal system undergo direct oxidative modification, a number of redox-regulated events are modulating the proteasomal activity in a way it can address the major tasks in an oxidative stress situation: the removal of oxidized proteins and the adaptation of the cellular metabolism to the stress situation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
