| Autor: |
LaRocca CD; Neurology Department, Vanderbilt University, Nashville, TN 37212., Wiley RG |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 1988 May 24; Vol. 449 (1-2), pp. 381-5. |
| DOI: |
10.1016/0006-8993(88)91059-1 |
| Abstrakt: |
Monoclonal anti-Thy 1 antibody (OX7) was pressure microinjected into vagus nerve, tongue or caudate nucleus of rats. Indirect anti-IgG immunoperoxidase staining showed that OX7 was axonally transported antero- and/or retrogradely from all injection sites. Histological examination and behavioral observations did not reveal neurotoxicity from these single OX7 injections. We conclude OX7 may prove useful as a carrier for selectively targeting molecules at neurons via endocytosis and axonal transport. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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