[Gastroenteropancreatic neuroendocrine tumors: clinical characteristics, diagnosis and prognosis at Hospital Universitario Clínico San Carlos (Madrid)].

Autor:	de Miguel Novoa MP; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España. Electronic address: pazdemiguel@telefonica.net., Fernández Capel F; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España., Redondo Sedano JV; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España., Sellers Carrera M; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España., Aranda Jiménez V; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España., Ortiz Pereira P; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España., Sastre Valera J; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España., Ortega Medina L; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España., Díaz Pérez JÁ; Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
Jazyk:	Spanish; Castilian
Zdroj:	Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion [Endocrinol Nutr] 2014 May; Vol. 61 (5), pp. 234-41. Date of Electronic Publication: 2014 Feb 20.
DOI:	10.1016/j.endonu.2013.12.001
Abstrakt:	Introduction: Neuroendocrine tumors are a group of neoplasms arising from the neural crest and endoderm and very heterogeneous as regards localization, clinical behavior, aggressiveness, and prognosis. Pancreas and gastrointestinal tract are the most common sites where neuroendocrine tumors can be found. Material and Methods: A review was made of all cases of neuroendocrine tumors diagnosed at Hospital Universitario Clínico San Carlos (HUCSC) from January 2007 to May 2012. Data were compared to the results provided by the Registry of the Spanish Group on Neuroendocrine Tumors (RGETNE). Results: The study cohort comprised 78 patients. Gastroenteric nonfunctional tumors were the most common neoplasms. Metastases were found at diagnosis in50.6% of patients, with nodal involvement being most prevalent. Tumors located in the rectum were associated to the highestrate of metastasis. Overall 2-year survival rate was 74.8% and was related to sex, Ki-67 expression, and presence of metastasis. (Copyright © 2013 SEEN. Published by Elsevier Espana. All rights reserved.)
Databáze:	MEDLINE
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