[Estimating the anti-inflammatory activity of drugs by changes in the agranulocyte/granulocyte index].

Autor: Platonov IA, Novikov VE, Iliukhin SA
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2013; Vol. 76 (11), pp. 28-32.
Abstrakt: It is suggested to assess the anti-inflammatory activity using the ratio of the sums of agranulocytes and granulocytes. On the model of carrageenan-induced inflammation in the rat limbs, the anti-inflammatory activity of NSAIDs and their combinations with antihypoxants was characterized in terms of limb size, leukogram, and the proposed index of anti-inflammatory activity. A high anti-inflammatory activity was observed for a combination of hypoxen with diclofenac and acetylsalicylic acid and a combination of metaprot with diclofenac.
Databáze: MEDLINE