The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness.

Autor:	Vuoksimaa E; Department of Psychiatry Center for Behavioral Genomics Twin Research Laboratory Department of Public Health, University of Helsinki, Helsinki, Finland., Panizzon MS; Department of Psychiatry Center for Behavioral Genomics Twin Research Laboratory., Chen CH; Department of Psychiatry Center for Behavioral Genomics Twin Research Laboratory., Fiecas M; Department of Psychiatry Center for Behavioral Genomics Twin Research Laboratory., Eyler LT; Department of Psychiatry Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA., Fennema-Notestine C; Department of Psychiatry Department of Radiology and., Hagler DJ; Department of Radiology and., Fischl B; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Computer Science and AI Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Franz CE; Department of Psychiatry Center for Behavioral Genomics Twin Research Laboratory., Jak A; Department of Psychiatry Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA., Lyons MJ; Department of Psychology, Boston University, Boston, MA, USA., Neale MC; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Rinker DA; Department of Psychiatry Department of Radiology and., Thompson WK; Department of Psychiatry., Tsuang MT; Department of Psychiatry Center for Behavioral Genomics Twin Research Laboratory., Dale AM; Department of Radiology and Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Kremen WS; Department of Psychiatry Center for Behavioral Genomics Twin Research Laboratory Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2015 Aug; Vol. 25 (8), pp. 2127-37. Date of Electronic Publication: 2014 Feb 18.
DOI:	10.1093/cercor/bhu018
Abstrakt:	Total gray matter volume is associated with general cognitive ability (GCA), an association mediated by genetic factors. It is expectable that total neocortical volume should be similarly associated with GCA. Neocortical volume is the product of thickness and surface area, but global thickness and surface area are unrelated phenotypically and genetically in humans. The nature of the genetic association between GCA and either of these 2 cortical dimensions has not been examined. Humans possess greater cognitive capacity than other species, and surface area increases appear to be the primary driver of the increased size of the human cortex. Thus, we expected neocortical surface area to be more strongly associated with cognition than thickness. Using multivariate genetic analysis in 515 middle-aged twins, we demonstrated that both the phenotypic and genetic associations between neocortical volume and GCA are driven primarily by surface area rather than thickness. Results were generally similar for each of 4 specific cognitive abilities that comprised the GCA measure. Our results suggest that emphasis on neocortical surface area, rather than thickness, could be more fruitful for elucidating neocortical-GCA associations and identifying specific genes underlying those associations. (© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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